| Scoring Summary |
| 1st Quarter |
| San Francisco Field Goal - 19-yarder by David Akers. 7:25 Time Remaining. (6 plays, 79 yards. Time of Drive: 3:17). |
| 2nd Quarter |
| Buffalo Field Goal - 31-yarder by Rian Lindell. 10:46 Time Remaining. (12 plays, 75 yards. Time of Drive: 5:44). |
| San Francisco Touchdown - 43-yard pass from Alex Smith to Kyle Williams. (David Akers extra point is good). 9:54 Time Remaining. (2 plays, 74 yards. Time of Drive: 0:52). |
| San Francisco Touchdown - 28-yard pass from Alex Smith to Michael Crabtree. (David Akers extra point is good). 0:24 Time Remaining. (1 plays, 28 yards. Time of Drive: 0:05). |
| 3rd Quarter |
| San Francisco Touchdown - 1-yard run by Frank Gore. (David Akers extra point is good). 9:06 Time Remaining. (5 plays, 66 yards. Time of Drive: 2:44). |
| 4th Quarter |
| San Francisco Touchdown - 10-yard pass from Alex Smith to Mario Manningham. (David Akers extra point is good). 14:12 Time Remaining. (13 plays, 94 yards. Time of Drive: 7:48). |
| San Francisco Touchdown - 16-yard run by Colin Kaepernick. (David Akers extra point is good). 9:55 Time Remaining. (7 plays, 67 yards. Time of Drive: 3:05). |
| San Francisco Touchdown - 3-yard run by Anthony Dixon. (David Akers extra point is good). 1:11 Time Remaining. (11 plays, 69 yards. Time of Drive: 6:29). |
| Final Team Statistics |
|---|
| | Buffalo | San Francisco |
|---|
| TOTAL FIRST DOWNS | 10 | 29 |
| By Rushing | 4 | 18 |
| By Passing | 6 | 11 |
| By Penalty | 0 | 0 |
| THIRD DOWN EFFICIENCY | 2-10-20 | 7-11-64 |
| FOURTH DOWN EFFICIENCY | 0-0-0 | 1-1-100 |
| TOTAL NET YARDS | 204 | 621 |
| Total Off. Plays (inc. times thrown passing) | 46 | 63 |
| Avg. gain per offensive play | 4.4 | 9.9 |
| NET YARDS RUSHING | 89 | 311 |
| Total Rushing Plays | 19 | 38 |
| Avg. gain per rushing play | 4.7 | 8.2 |
| NET YARDS PASSING | 115 | 310 |
| Times Thrown - yards lost attempting to pass | 1-11 | 0-0 |
| Gross yards passing | 126 | 310 |
| PASS ATTEMPTS-COMPLETIONS-HAD INTERCEPTED | 26-16-1 | 25-19-0 |
| Avg. gain per pass play (inc. # thrown passing) | 4.3 | 12.4 |
| PUNTS Number and average | 6-47.7 | 2-56.0 |
| Net Punting Average | 41.2 | 42.0 |
| TOTAL RETURN YARDAGE (Not including kickoffs) | 28 | 23 |
| No. and Yards Punt Returns | 1-28 | 3-19 |
| No. and Yards Kickoff Returns | 2-87 | 2-45 |
| No. and Yards Interception Returns | 0-0 | 1-4 |
| PENALTIES No. and Yards | 5-30 | 7-53 |
| FUMBLES No. and Lost | 1-1 | 1-1 |
| TOUCHDOWNS | 0 | 6 |
| Rushing | 0 | 3 |
| Passing | 0 | 3 |
| EXTRA POINTS Made-Attempts | 0-0 | 6-6 |
| FIELD GOALS Made-Attempts | 1-1 | 1-1 |
| SAFETIES | 0 | 0 |
| FINAL SCORE | 3 | 45 |
| TIME OF POSSESSION | 23:43 | 36:17 |
| Final Individual Statistics |
|---|
| Buffalo | San Francisco |
| |
| PASSING | ATT | CP | YDS | SK/YD | TD | LG | IN |
|---|
| R.Fitzpatrick | 26 | 16 | 126 | 1/11 | 0 | 20 | 1 | | | | | | | | | | | Total | 26 | 16 | 126 | 1/11 | 0 | 20 | 1 |
| |
| |
| INTERCEPTIONS | NO | YDS | LG | TD |
|---|
| None | | Total | 0 | 0 | 0 | 0 |
| |
| PUNTING | NO | YDS | AVG | TB | IN20 | LG |
|---|
| S.Powell | 6 | 286 | 47.7 | 1 | 2 | 59 | | Total | 6 | 286 | 47.7 | 1 | 2 | 59 |
| | PUNTING | NO | YDS | AVG | TB | IN20 | LG |
|---|
| A.Lee | 2 | 112 | 56.0 | 0 | 1 | 58 | | Total | 2 | 112 | 56.0 | 0 | 1 | 58 |
|
| PUNT RETURNS | NO | FC | YDS | LG | TD |
|---|
| L.McKelvin | 1 | 0 | 28 | 28 | 0 | | DOWNED | 1 | 0 | 0 | 0 | 0 | | | | | | | | | Total | 2 | 0 | 28 | 28 | 0 |
| | PUNT RETURNS | NO | FC | YDS | LG | TD |
|---|
| T.Ginn Jr. | 3 | 0 | 19 | 11 | 0 | | OUT OF BOUNDS | 2 | 0 | 0 | 0 | 0 | | TOUCHBACK | 1 | 0 | 0 | 0 | 0 | | Total | 6 | 0 | 19 | 11 | 0 |
|
| KICKOFF RETURNS | NO | FC | YDS | LG | TD |
|---|
| L.McKelvin | 1 | 0 | 59 | 59 | 0 | | B.Smith | 1 | 0 | 28 | 28 | 0 | | TOUCHBACK | 6 | 0 | 0 | 0 | 0 | | Total | 8 | 0 | 87 | 59 | 0 |
| | KICKOFF RETURNS | NO | FC | YDS | LG | TD |
|---|
| K.Williams | 2 | 0 | 45 | 28 | 0 | | | | | | | | | | | | | | | | Total | 2 | 0 | 45 | 28 | 0 |
|
| KICKING | FG | PCT | LG | XP | PTS |
|---|
| R.Lindell | 1/1 | 100.0 | 31 | 0/0 | 3 | | Total | 1/1 | 100.0 | 31 | 0/0 | 3 |
| | KICKING | FG | PCT | LG | XP | PTS |
|---|
| | | | | | | | Total | 1/1 | 100.0 | 19 | 6/6 | 9 |
|